Background: The antimicrobial and anti-inflammatory activity of honey and its ability to accelerate wound healing make it an attractive option in surgical wound care. We performed a randomized clinical trial to compare the efficacy of honey dressing with conventional dressing regarding the aesthetic outcome. Patients and Methods: Bilateral symmetric incisions in randomly selected plastic surgical patients were randomly covered postoperatively with conventional dressing and honey dressing for five days. The aesthetic outcome of the two sides was rated on a Visual Analog Scale by the surgeon and the patient and compared at month three and six after surgery. Results: Seventy two symmetrical incisions in 52 patients were evaluated during the study. The mean width of the scar after the third and the sixth month was 3.64 +/- 0.83 mm and 3.49 +/- 0.87 mm on the side that received honey dressing and 5.43 +/- 0.05 mm and 5.30+/- 1.35 mm in the control group. Wilcoxon signed-rank test showed significant difference between honey and conventional dressing outcomes at third and sixth month (p < 0.001). Conclusion: The healing process of the surgical wound and its final aesthetic result could be improved by using honey dressing.

1.
Dunford C, Cooper R, Molan P, White R: The use of honey in wound management. Nurs Stand 2000;15:63-68.
[PubMed]
2.
Lusby P, Coombes A, Wilkinson JM: Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs 2002;29:295-300.
[PubMed]
3.
Namias N: Honey in the management of infections. Surg Infect (Larchmt) 2003;4:219-226.
[PubMed]
4.
Sharp A: Beneficial effects of honey dressing in wound management. Nurs Stand 2009;24:66-68.
[PubMed]
5.
Ashoor A: The Hospital of Honey - Medical Treatment by Honey. Cairo, Al Quran Library, 1985.
6.
Boyce JM: Methicillin-resistant Staphylococcus aureus. Detection, epidemiology, and control measures. Infect Dis Clin North Am 1989;3:901-913.
[PubMed]
7.
Robson V, Dodd S, Thomas S: Standardized antibacterial honey (Medihoney) with standard therapy in wound care: randomized clinical trial. J Adv Nurs 2009;65:565-575.
[PubMed]
8.
Li J, Chen J, Kirsner R: Pathophysiology of acute wound healing. Clin Dermatol 2007:25:9-18.
[PubMed]
9.
Greaves NS, Ashcroft KJ, Baguneid M, Bayat A: Current understanding of molecular and cellular mechanisms in &#xFB01;broplasia and angiogenesis during acute wound healing. J Dermatol Sci 2013;72:206-217.
[PubMed]
10.
Jull AB, Rodgers A, Walker N: Honey as a topical treatment for wounds. Cochrane Database Syst Rev 2008; CD005083.
[PubMed]
11.
Molan PC: The antibacterial activity of honey: the nature of the antibacterial activity. Bee World 1992;73:5-28.
12.
Molan PC: The antibacterial activity of honey: variation in the potency of the antibacterial activity. Bee World 1992;73:59-76.
13.
Molan PC: Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2001;2:13-19.
[PubMed]
14.
Molan PC: Re-introducing honey in the management of wounds and ulcers-theory and practice Ostomy Wound Manage 2002;48:28-40.
[PubMed]
15.
Molan PC: The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 2006;5:40-54.
[PubMed]
16.
Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A: Honey stimulates inflammatory cytokine production from monocytes. Cytokines 2003;21:242-247.
[PubMed]
17.
Tonkes A, Cooper RA, Price AJ, Molan PC, Jones KP: Stimulation of TNF-alpha release in monocytes by honey. Cytokine 2001;14:240-242.
[PubMed]
18.
Simon A, Traynor K, Santos K, Blaser G, Bode U, Molan P: Medical honey for wound care - still the ‘latest resort'? Evid Based Complement Alternat Med 2009;6:165-173.
[PubMed]
19.
Bergman A, Yanai J, Weiss J, Bell D, David M: Acceleration of wound healing by topical application of honey. An Animal Model. Am J Surg 1983;145:374-376.
[PubMed]
20.
Gupta S, Singh H, Varshney A, Prakash P: Therapeutic efficacy of honey in infected wounds in buffaloes. Indian J Anim Sci 1992;62:521-523.
21.
Tonks AJ, Dudley E, Porter NG, et al.: A 5.8-kDa component of manuka honey stimulates immune cells via TLR4. J Leukoc Biol 2007;82:1147-1155.
[PubMed]
22.
Rushton I: Understanding the role of proteases and PH in wound healing. Nurs Stand 2007;21:68-72.
[PubMed]
23.
Schneider LA, Korber A, Grabbe S, Dissemind J: Influence of PH on wound-healing: a new perspective for wound therapy? Arch Dermatol Res 2007;298:413-420.
[PubMed]
24.
Rendel M, Mayer C, Weninger W, Tschachler E: Topically applied of lactic acid increases spontaneous secretion of vascular endothelial growth factor by human constructed epidermis. Br J Dermatol 2001;145:3-9.
[PubMed]
25.
Majtán J: Apitherapy - The role of honey in the chronic wound healing process. Epidemiol Mikrobiol Imunol 2009;58:137-140.
[PubMed]
26.
Biglari B, Moghaddam A, Santos K, et al.: Multicentre prospective observational study on professional wound care using honey (Medihoney™). Int Wound J 2013:252-259.
[PubMed]
27.
Fitzmaurice SD, Sivamani RK, Isseroff RR: Antioxidant therapies for wound healing: a clinical guide to currently commercially available products. Skin Pharmacol Physiol 2011;24:113-126.
[PubMed]
You do not currently have access to this content.