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Original Paper

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Enhancement of Neural Salty Preference in Obesity

Li Q.a · Jin R.b · Yu H.a · Lang H.a · Cui Y.a · Xiong S.a · Sun F.a · He C.a · Liu D.a · Jia H.c · Chen X.d · Chen S.e · Zhu Z.a

Author affiliations

aDepartment of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China
bDepartment of Medical Image, Daping Hospital, Third Military Medical University, Chongqing, China
cSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China
dBrain Research Center, Third Military Medical University, Chongqing, China
eTeaching and Research Office for Geriatric Disease, First Affiliated Hospital of China Medical University, Shenyang, China

Corresponding Author

Zhiming Zhu,

Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases,

Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, (China);

E-Mail zhuzm@yahoo.com

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Cell Physiol Biochem 2017;43:1987–2000

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Background/Aims: Obesity and high salt intake are major risk factors for hypertension and cardiometabolic diseases. Obese individuals often consume more dietary salt. We aim to examine the neurophysiologic effects underlying obesity-related high salt intake. Methods: A multi-center, random-order, double-blind taste study, SATIETY-1, was conducted in the communities of four cities in China; and an interventional study was also performed in the local community of Chongqing, using brain positron emission tomography/computed tomography (PET/CT) scanning. Results: We showed that overweight/obese individuals were prone to consume a higher daily salt intake (2.0 g/day higher compared with normal weight individuals after multivariable adjustment, 95% CI, 1.2-2.8 g/day, P < 0.001), furthermore they exhibited reduced salt sensitivity and a higher salt preference. The altered salty taste and salty preference in the overweight/obese individuals was related to increased activity in brain regions that included the orbitofrontal cortex (OFC, r = 0.44, P= 0.01), insula (r = 0.38, P= 0.03), and parahippocampus (r = 0.37, P= 0.04). Conclusion: Increased salt intake among overweight/obese individuals is associated with altered salt sensitivity and preference that related to the abnormal activity of gustatory cortex. This study provides insights for reducing salt intake by modifying neural processing of salty preference in obesity.

© 2017 The Author(s). Published by S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 24, 2017
Accepted: August 10, 2017
Published online: October 20, 2017
Issue release date: December 2017

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 3

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: https://www.karger.com/CPB

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