B Cell Biology in Autoimmunity
Nemazee D. (La Jolla, Calif.)
Publication year: 2002
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Current Directions in Autoimmunity , Vol. 6
Editor(s): Theofilopoulos A.N. (La Jolla, Calif.)
VIII + 272 p., 43 fig., 4 in color, 14 tab., hard cover, 2002
This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS.
Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.