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Mechanisms of Dietary Restriction in Aging and Disease

Mobbs C.V. (New York, N.Y.) 
Yen K. (New York, N.Y.) 
Hof P.R. (New York, N.Y.) 

Status: available   
Publication year: 2007
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Digital Version: CHF 188.00, EUR 176.00, USD 221.00
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This book belongs to
Interdisciplinary Topics in Gerontology and Geriatrics , Vol. 35
Editor(s): Fulop T. (Sherbrooke, Que.) 
VIII + 198 p., 23 fig., 5 tab., hard cover, 2007
Status: available   
ISSN: 2297-3508
e-ISSN: 2297-3486

Dietary interventions to expand lifespan
Dietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the National Institute of Aging convened a program involving several leading gerontological laboratories. Results from many of these, as well as from other leading research institutions in the field, are presented in this book. The first three papers address general molecular mechanisms, derived in part from recent DNA microarray studies, that may mediate protective effects of dietary restriction. The subsequent articles examine specific model systems, including flies, nematodes and non-human primates, that have provided exciting new information about these mechanisms. Finally, mechanisms of dietary restriction mediating protective effects against cancer and neurological diseases are discussed.
In addition to gerontologists and geriatricians, many other medical and nonmedical professionals in the field will find a great wealth of information on possible interventions that may ameliorate age-related diseases.