Early Life Origins of Human Health and Disease

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Editor(s): Newnham, J.P. (Perth, WA)
Ross, M.G. (Los Angeles, CA)

Status: available   
Publication year: 2009
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Reviews


'The discipline-wise approach in the book, which deals with the evidence in each area – spanning the role of nutritional interventions and epigenetics, early embryonic environment, environmental exposures, development of the lung, musculoskeletal, renal and immune systems, development of the foetal hypothalamic-pituitary-adrenal-placental axis and the economic implications of DoHAD – presented by experts in the field, is helpful in guiding readers to their core areas of interest.'
Poornima Prabhakan
Public Health Foundation of India, School of Social and Community Medicine, University of Bristol
The National Medical Journal of India 24/3/May-June 2011


'As a result of the high scientific quality of the contributions to the book, it certainly will stimulate the readers to investigate various biomedical problems, such as the molecular background of various listed pathological conditions.'
Rolf Zetterstrôm
Acta Paediatrica 99/4/2010


'This book makes absorbing reading for the clinician and researchers interested in the biology of chronic non communicable diseases. This book is a 'must' read eye-opener for the guardians of national health and economy.'
Shashi Wadhwa
Department of Anatomy, All India Institute of Medical Sciences
Indian Journal of Medical Research 131/5/2010


'The concept of developmental origins of health and disease (DOHaD) has provided new insight into the pathogenesis of disease. ...
It is important that every pediatrician is aware of the concept of DOHaD. As stated in the first chapter "developmental plasticity and DOHaD", it is necessary to promote a healthy life through a life course approach. The life course approach recognizes important factors occurring at each stage of life rather than viewing health and disease statically. It may then become possible to modify or even reverse adverse effects postnatally by adjusting environment. The concept of DOHaD plays an important role socio-economically as well as scientifically in both developed and developing countries. Thus it needs to be spread to the general public and politicians who decide nation or worldwide health policy affecting the next generation. The role of pediatricians is enormous in promoting parental education and in advocating for children's as well as global health.
... the book is full of recent knowledge, concise, and useful for experts, clinicians, and anyone interested in health care. One can enjoy reading it straight through, and each chapter can be used as a reference guide at the same time.'
Midori Awazu, M.D.
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
Pediatrics International 52/2/2010
Discover and benefit from a promising area of health care
A Karger 'Publishing Highlights 1890–2015' title

There is compelling evidence that many of the risks leading to the most frequent chronic diseases in adulthood originate in the earliest stages of life. Adverse environmental conditions in utero and during infancy can lead to negative health effects during the subsequent lifetime of the exposed individual.
This book offers precious insights into the latest concepts and results from epidemiologic, clinical and basic studies in this burgeoning area of health care. The developmental origins of various diseases such as diabetes, obesity and cancer are examined, as well as the early programming of reproductive health and different organs. Attention is given to the impact of environmental factors such as nutrition and pollution, and the mediating genetic and epigenetic pathways are reviewed. A crucial point under discussion is the concept of environmental insults adversely affecting not only the exposed persons, but also their descendants. In addition, the economic consequences of a suboptimal start to life and the importance of preventive measures are stressed.
This publication is of great value to anyone interested in health care, notably to specialists in obstetrics, pediatrics, internal medicine, obesity, diabetes and heart disease.

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