New Drugs and Targets for Asthma and COPD

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Editor(s): Hansel, T.T. (London)
Barnes, P.J. (London)

Status: available   
Publication year: 2010
Available online since: 2011
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This book belongs to
Progress in Respiratory Research , Vol. 39
Editor(s): Herth, F.J.F. (Heidelberg)
XIV + 310 p., 80 fig., 67 in color, 46 tab., hard cover, 2010
Status: available   
ISSN: 1422-2140
e-ISSN: 1662-3932


Read the reviews

Reviews
‘The text appears to provide comprehensive coverage of the mechanistic approaches and compounds currently available or under study. For the interested reader, this tertiary text brings together information that would otherwise require extensive research of the primary literature….
This book is a focused reference, highly recommended for any medical or pharmaceutical library. It is also appropriate for the personal library of industry, academic, and clinical researchers and practitioners with a very specialized interest in respiratory disease.’
Theresa R. Prosser, PharmD, Professor of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO
(The Annals of Pharmacotherapy, Vol. 45, March 2011)



‘Overall, this is an excellent introduction to what has happened in the last 8–10 years and what is likely to happen in the next decade in the treatment of airway obstruction. It seems that the drug companies will remain busy with a rapid turn around of new drugs and molecules. The presentation and printing are also attractive with clear coloured figures, flow-diagrams and tables. It is a valuable book for the respiratory research workers, pharmacologists and physicians.’
S.K. Jindal, Dept. of Pulmonary Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India
(Indian Journal of Medical Research, Vol. 133, June 2011)



«Trevor Hansel und Peter Barnes gehören ohne jeden Zweifel zu den höchst angesehenen Forschern auf dem Gebiet der Pathophysiologie obstruktiver Atemwegserkrankungen. Sie haben nicht wenig dazu beigetragen, das Mosaik von Mediatoren, Zellen und biochemischen Mechanismen zusammenzufügen….
Zahlreiche Experten, überwiegend aus Grossbritannien und den USA, bearbeiten in kurzen, übersichtlichen Abschnitten das Spektrum von Substanzen, die direkt bronchodilatatorisch wirken oder zelluläre Muster, Mediatoren oder Zytokine beeinflussen. Dabei folgen sie locker einer Reihenfolge vom Ziel des therapeutischen Ansatzes über präklinische und klinische pharmakologische Studien bis hin zur kritischen Würdigung der Substanzen….
Dieses Buch ermöglicht einen Blick auf zukünftige Optionen, von denen manches bald, manches erst in einigen Jahren und manches vielleicht nie umgesetzt werden kann….
…Das Werk dürfte Handbuch für Pharmakologen in klinischer und Grundlagenforschung werden.»
Prof. Dr. med. Winfried J. Randerath, Solingen (Arzneimitteltherapie Vol. 28, No. 12, 2010)
Reporting the latest progress
Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world.
This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors.

Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.

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