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Cover

Genetics of Human Infertility

Editor(s): Vogt P.H. (Heidelberg) 

Status: available   
Publication year: 2017
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Digital Version: CHF 168.00, EUR 157.00, USD 198.00
Print Version: CHF 168.00, EUR 157.00, USD 198.00
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This book belongs to
Monographs in Human Genetics , Vol. 21
Editor(s): Schmid M. (Würzburg) 
X + 178 p., 24 fig., 16 in color, 8 tab., hard cover, 2017
Status: available   
ISSN: 0077-0876
e-ISSN: 1662-3835

A broad treatise on the complex genetic causes of human infertility
Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects.

Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods.

This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.