Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Fetal Diagnosis and Therapy

Clinical Advances and Basic Research

Guidelines for Authors

Scope and Vision
Categories of Manuscripts
Plagiarism Policy
Instructions for Preparation of Specific Manuscript Categories
Color Illustrations
Digital Object Identifier (DOI)
Supplementary Material
Self-Archiving/Green Open Access, Author's ChoiceTM,
   Funding Organizations (NIH etc.)

Page Charges
E-pub First

Scope and Vision

The scope of 'Fetal Diagnosis and Therapy' is fetal medicine in its broadest sense, including basic science and pathophysiological issues, prenatal diagnosis, clinical management and fetal therapy. The journal's main goal is to provide useful information and new insights into fetal diagnosis and therapy in the form of original research, reviews and relevant clinical cases and images. Our vision is to become a journal of reference for the multidisciplinary audience of professionals involved in clinical practice and research in fetal medicine.

Authors should ensure that their work complies with all regulations laid down by their state or community and should have obtained the necessary informed consent. Neither the editors nor the publishers will accept any responsibility in the case of neglect or avoidance of these rules.


Manuscripts written in English should be submitted online along with the names, postal and e-mail addresses of at least four experts in the appropriate area of research. Selected scientist(s) will be invited to act as referee(s). Referees suggested should not be from the same institution as the author and should have expert knowledge of the subject.

Should you have any problems with your submission, please contact:

Patricia Bachmann
Editorial Office 'Fetal Diagnosis and Therapy'
S. Karger AG
P.O. Box
CH–4009 Basel (Switzerland)
Tel. +41 61 306 1359
Fax +41 61 306 1434

The manuscripts should be accompanied by a signed copyright transfer statement (please see submission website).

Presentation of manuscripts should conform with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals [N Engl J Med 1997;336:309–315].


All manuscripts are subject to editorial review. Manuscripts are received with the explicit understanding that they are not under simultaneous consideration by any other publication. Submission of an article for publication implies transfer of the copyright from the author to the publisher upon acceptance. Accepted papers become the permanent property of 'Fetal Diagnosis and Therapy' and may not be reproduced by any means, in whole or in part, without the written consent of the publisher. It is the author's responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications.

For legal reasons, we must receive your 'Submission Statement' with your original (hand-written) signature. Please download, print, sign and either fax or scan it to make it legally binding.

Any financial (funding, stocks, patents, employment, honoraria, royalties) or non-financial (political, personal, professional) interests/relationships that may be interpreted to have influenced the manuscript must be identified in a 'Conflicts of Interest' statement at the end of the manuscript. If there is no conflict of interest, please state "The authors declare no conflicts of interest".

Categories of Manuscripts

The journal is structured into five categories.

Original Papers
Authors are invited to submit their research to the journal. Papers will be classified into four areas of interest.
 ·  Basic Science and Pathophysiology
 ·  Prenatal Diagnosis
 ·  Clinical Fetal Medicine
 ·  Fetal Therapy

Reviews and Mini-Reviews
Reviews on specific questions or topics which are felt to be of interest to the majority of readers; normally, but not exclusively, on clinical issues. They should be concise reviews or mini-reviews which give evidence and provide an answer to a well-defined aspect or question in a particular area. These reviews are normally invited but suggestions for reviews will also be considered, particularly systematic reviews accompanying a case report or case series if they are deemed to be timely and of high quality. Accepted reviews are not subject to page charges.

Novel Insights from Clinical Practice (formerly Case Reports)
While the main aim of the journal is to publish original research and reviews, case reports which provide relevant insights into the background knowledge or which illustrate an extremely unusual clinical course are welcome. In general, case reports with a review of the literature are discouraged and this option should be reserved for exceptional cases, when the review is deemed to be of very high quality and value to the reader.

Images in Fetal Medicine
The section aims to publish images of high interest, either because they illustrate or aid understanding of an important concept or because the image is of particular quality. Images of all kinds are foreseen, including ultrasound, MRI and fetoscopy. Combinations of prenatal imaging with fetoscopic, postnatal, surgical or pathological imaging are particularly encouraged. Authors may be invited to transfer some clinical cases to this section if the images are particularly good. Papers published in this section will be considered as case reports for Medline purposes.

Letters to the Editor
Letters are encouraged if they directly concern articles previously published in this journal or clinical subjects related to the matters discussed. The editor reserves the right to submit copies of such letters to the authors of the articles concerned prior to publication in order to permit them to respond in the same issue of the journal. Letters on general scientific or medical subjects in fetal medicine are also welcome.

Plagiarism Policy

Whether intentional or not, plagiarism is a serious violation. We define plagiarism as a case in which a paper reproduces another work with at least 25% similarity and without citation.
If evidence of plagiarism is found before/after acceptance or after publication of the paper, the author will be offered a chance for rebuttal. If the arguments are not found to be satisfactory, the manuscript will be retracted and the author sanctioned from publishing papers for a period to be determined by the responsible Editor(s).


Title page: The first page of each paper should indicate the title, the authors' names, and the institute where the work was conducted. A short title for use as a running head, as well as the full address of the author to whom correspondence should be sent, are also required.

Full address: The exact postal address of the corresponding author complete with postal code must be given at the bottom of the title page. Please also supply phone and fax numbers, as well as e-mail address.

Key words: Please supply 3–10 key words in English that reflect the content of the paper.

Abstract: Please refer to the 'Instructions for Preparation of Specific Manuscript Categories'.

Footnotes: Avoid footnotes. When essential, they are numbered consecutively and typed at the foot of the appropriate page.

Tables and illustrations: Tables and illustrations (both numbered in Arabic numerals) should be prepared on separate sheets. Tables require a heading and figures a legend, also prepared on a separate sheet. For technical reasons, figures with a screen background should not be submitted. When possible, group several illustrations in one block for reproduction (max. size 180 x 223 mm) or provide crop marks. Each illustration must be labelled with its number and the first author's name. B/w half-tone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800–1,200 dpi. Figure files must not be embedded in a document file but submitted separately (see also Online Submission Instructions).

Instructions for Preparation of Specific Manuscript Categories

Original Papers
The guidelines below should be followed as closely as possible. This will help the editors and reviewers to interpret the aims and value of your research.
An abstract of up to 200 words, structured with the same headings as below, should be provided.

This should clearly state the research question and introduce the condition and the clinical or research problem being addressed. Lengthy descriptions of previous evidence, particularly information that may be important for the topic in general but is not strictly related to the research question, should be avoided. At the end of the introduction please clarify what new or complementary information your research is providing with respect to existing knowledge or previous research.

Material and Methods
The section must contain clear information on permissions obtained by ethical committees, inclusion and exclusion criteria, methods of research, variables evaluated and main outcome measures, along with other secondary variables evaluated, definitions used, and statistical analyses.

The findings of the study should be described concisely following the same structure as in Materials and Methods. The text should complement, but not duplicate, the information contained in the tables and figures. Comments on the findings in this section should be avoided.

The Discussion should be as structured as possible, and contain at least the following paragraphs, each with information responding to the following questions:
 ·  What are the main findings?
 ·  How do they compare with previous studies: which are the similarities and
    differences and the reasons for them?
 ·  What are the pathophysiological basis and insights reinforced or newly provided by
    the findings? (If applicable.)
 ·  What is the clinical relevance of the findings?
 ·  What are the main limitations of the study?
 ·  If applicable, a concluding paragraph on potential future lines of research which
    must be considered according to previous data and/or this particular study.

Mini-reviews may have the structure of a conventional or systematic review. They must be clearly addressed to respond to a specific question of clinical practice or special pathophysiological importance which will normally be pre-defined by invitation of the Editorial Board. 3,000–4,000 words long, they may contain tables and figures and an unlimited number of references.

Systematic Reviews
Both abstract and paper should be structured according to the following scheme: Background/Objectives, Data Sources, Results and Discussion. It is particularly important to precisely describe the methodology used for the systematic review, including data sources, number of reviewers and the pre-established criteria used for the search and classification of papers. If the review is accompanied by a case report or a small case series, the Results section must be divided into two subsections: 'Case Report/Series' and 'Systematic Review of...'. The number of references is unlimited.

Novel Insights from Clinical Practice (formerly Case Reports)
The publication space available for case reports is very limited. The journal only considers case reports with significant new insights or with an extremely unusual and memorable course. Highlighted boxes containing one or two bullet points on 'Established facts' (what is already known) and 'Novel insights' (what new information has been gained) are required and should be placed on the first page of the report (after title page). These should be selected so as to reinforce the novelty of the clinical observation.

Established Facts

  ·    Already known fact 1 ...     

  ·    Already known fact 2 ...

  ·     ...

Novel Insights

  ·    New information 1 ...         

  ·    New information 2 ...

  ·     ...

Novel Insights from Clinical Practice must be written concisely and structured as follows:
 ·  A non-structured Abstract (max. 200 words), for Medline purposes.
 ·  No introduction section is required.
 ·  A description of the Clinical Case.
 ·  To illustrate the case the numbers of figures should be kept to a minimum,
    i.e. notmore than three. More images are accepted in justified cases.

Images in Fetal Medicine
Images must be accompanied by a brief text, structured in the same way as a Case Report, but considerably shorter in length, and limited to the essential. Ideally, there should be three references (five is the maximum number allowed). Where appropriate a Summary Points box can be provided to summarize the novel insights.

Letters to the Editor
Letters should be no longer than one printed page and must concern articles previously published in this journal or clinical subjects related to the matters discussed.

Color Illustrations

Online edition: Color illustrations are reproduced free of charge. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends.

Print edition: Up to 6 color illustrations per page can be integrated within the text at CHF 960.00 per page.


In the text identify references by Arabic numerals [in square brackets]. Material submitted for publication but not yet accepted should be noted as 'unpublished data' and not be included in the reference list. The list of references should include only those publications which are cited in the text. Do not alphabetize; number references in the order in which they are first mentioned in the text. The surnames of the authors followed by initials should be given. There should be no punctuation other than a comma to separate the authors. Cite all authors, 'et al' is not sufficient. Abbreviate journal names according to the Index Medicus system. Also see International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals (www.icmje.org).


(a) Papers published in periodicals: Sun J, Koto H, Chung KF: Interaction of ozone and allergen challenges on bronchial responsiveness and inflammation in sensitised guinea pigs. Int Arch Allergy Immunol 1997;112:191–195.

(b) Papers published only with DOI numbers: Theoharides TC, Boucher W, Spear K: Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients. Int Arch Allergy Immunol DOI: 10.1159/000063858.

(c) Monographs: Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 3, revised. Basel, Karger, 1996.

(d) Edited books: Parren PWHI, Burton DR: Antibodies against HIV-1 from phage display libraries: Mapping of an immune response and progress towards antiviral immunotherapy; in Capra JD (ed): Antibody Engineering. Chem Immunol. Basel, Karger, 1997, vol 65, pp 18–56.

Reference Management Software: Use of EndNote is recommended for easy management and formatting of citations and reference lists.

Digital Object Identifier (DOI)

S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at www.doi.org

Supplementary Material

Multimedia files and other supplementary files, directly relevant but not essential to the conclusions of a paper, enhance the online version of a publication and increase its visibility on the web. These files will undergo editorial review. The Editors reserve the right to limit the scope and length of the supplementary material. Multimedia and supplementary material should meet production quality standards for publication without the need for any modification or editing. Files should not exceed 10 MB in size. Figures and tables need to have titles and legends, and all files should be supplied separately and labeled clearly. All supplementary material should be referred to in the main text. A DOI number will be assigned to supplementary material and it will be hosted online at https://karger.figshare.com under a CC BY license. Authors will be charged a processing fee of CHF 250.00 for supplementary material.

Self-Archiving/Green Open Access

Karger permits authors to archive their pre-prints (i.e. pre-peer review) or post-prints (i.e. accepted manuscript after peer review but before production) on their personal or their institution’s internal website. In addition, authors may post their accepted manuscripts in public Open Access repositories and scientific networks (e.g. ResearchGate or Mendeley) no earlier than 12 months following publication of the final version of their article. For all self-archiving, the posted manuscripts must:

  • Be used for noncommercial purposes only
  • Be linked to the final version on www.karger.com
  • Include the following statement:

‘This is the peer-reviewed but unedited manuscript version of the following article: [insert full citation, e.g. Cytogenet Genome Res 2014;142:227–238 (DOI: 10.1159/000361001)]. The final, published version is available at http://www.karger.com/?doi=[insert DOI number].’

It is the author’s responsibility to fulfill these requirements.

For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article.

Manuscripts to be archived in PubMed Central due to funding requirements will be submitted by Karger on the author’s behalf [see Funding Organizations (NIH etc.)].

For self-archiving Author's ChoiceTM (Gold Open Access) articles, see Author's ChoiceTM.

Author's ChoiceTM

Karger’s Author's ChoiceTM service broadens the reach of your article and gives all users worldwide free and full access for reading, downloading and printing at www.karger.com. The option is available for a one-time fee of CHF 3,000.00, which is a permissible cost in grant allocation. More information can be found at www.karger.com/authors_choice.
The final, published version of the article may be posted at any time and in any repository or on other websites, in accordance with the relevant Creative Commons license. Reposted Open Access articles must:

  • Follow the terms of the relevant Creative Commons license
  • Be linked to the final version on www.karger.com
  • Include the following statement:

‘The final, published version of this article is available at http://www.karger.com/?doi=[insert DOI number].’

It is the author’s responsibility to fulfill these requirements.

For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article.

Funding Organizations (NIH etc.)

The U.S. National Institutes of Health (NIH) Public Access Policy mandates that accepted, peer-reviewed manuscripts are archived in its digital database, PubMed Central (PMC), within 12 months of the official publication date. As a service to authors, Karger submits NIH-funded articles to PMC on behalf of the authors immediately upon publication. The NIH assigns a PMCID within approximately 1 month and the manuscript will appear in PMC after a 12-month embargo. For authors making their paper Open Access through Author's ChoiceTM, the embargo will be overridden, thereby accelerating the accessibility of the article. Karger also complies with other funders’ requirements (including Wellcome Trust and RCUK) for submission to PMC.
Authors should include information on their grant in the Acknowledgements section of their papers.

Page Charges

There are no page charges for papers of 4 or less printed pages (including tables, illustrations and references). Each additional complete or partial page is charged to the author at CHF 325.00. The allotted size of a paper is equal to approx. 12 manuscript pages (including tables, illustrations and references).


Unless indicated otherwise, a PDF for correction is sent to the corresponding author and should be returned with the least possible delay. Alterations other than the correction of printer's errors are charged to the author.

E-pub First

All articles are published electronically ahead of print with a DOI number and are supplemented later with the definite reference of the printed version. The articles become available immediately after the authors' approval to publication, with the added advantage of being citable much earlier than in print. Authors can influence the time of appearance by promptly returning the proofs.


Order forms and a price list are sent with the PDF. Orders submitted after the issue is printed are subject to considerably higher prices.