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Medical Principles and Practice

International Journal of the Kuwait University Health Sciences Centre

Guidelines for Authors with Online Submission Instructions
www.karger.com/mpp_guidelines

Medical Principles and Practice, as the journal of the Health Sciences Centre, Kuwait University, aims to be a publication of international repute that will be a medium for dissemination and exchange of scientific knowledge in the health sciences.

Journal Policies
Free Open Access
Copyright
Peer Review
Ethics
Conflict of Interest
Self-Archiving
NIH-Funded Research
Authors' Contributions
Charges
Use of Digital Object Identifier (DOI)

Preparing Your Manuscript
Article Types
Title Page
Significance of the Study
Abstract
Arrangement
Supplementary Material
References

Language
Usage and Editing Service

Submission
Submitting Your Manuscript
Submission Statement
Cover Letter
Submission Checklist

After Acceptance
Advanced Release
Copy Editing and Proofing
Reprints

Author Inquires
From Submission to Acceptance
After Acceptance


Journal Policies


Free Open Access

Medical Principles and Practice is a peer-reviewed and free open access journal – researchers read full-text free of charge and also publish free of charge. Articles can be read, downloaded, printed, and shared provided that use is for noncommercial purposes only, and proper credit is given to the authors as well as the original publisher. All articles in this Journal are Free Open Access and meet the requirements of funding bodies or academic institutions.

Articles are licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International license (CC BY-NC).

Please contact Karger's Open Access team at openaccess@karger.com with questions regarding your funding body.




Copyright

Copyright of the manuscripts is retained by the authors. Authors grant S. Karger AG, Basel, an exclusive unlimited license to publish the article under a Creative Commons license and identify S. Karger AG as the original publisher. Submission of an article for publication implies the authors’ consent to publication under the applicable Creative Commons license and the terms and conditions of the Publisher’s Licensing Agreement.




Peer Review

All submitted manuscripts are reviewed by the editors for adequacy of documentation, composition, and adherence to the guidelines of the Journal. Manuscripts considered suitable for review are sent to two reviewers for evaluation. All reviews are confidential. The reviewers are asked to assess the originality, scientific merit, and design of the study, including statistical analysis, professional interest, and overall quality of the manuscript. The reviewer may recommend the manuscript be accepted as is, be revised, or be rejected. It is unusual for a manuscript to be accepted without having undergone any revision. The deadline for submission of the revised manuscript is 1 month from the date when the reviewers' comments are sent to the corresponding author. The revised manuscript is then reviewed for compliance with the reviewers' recommendations and, if deemed acceptable, is edited for clarity, accuracy, and style.




Ethics

Research Ethics: Research must comply with the guidelines for human studies and animal welfare regulations. Manuscripts reporting studies on human subjects should include evidence that the research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. In particular, authors must state in a Statement of Ethics at the end of the manuscript that subjects (or their parents or guardians) have given their informed written consent and that the study protocol was approved by an appropriate ethics committee. All patients should be identified by numbers or aliases, not by their real names. For clinical trials, registration in a public trials registry at or before the time of first patient enrollment is a condition of consideration for publication. The trial registration number must be provided upon submission. Authors should also state that animal experimentation was approved by the appropriate institutional review body. Copies of these guidelines and policy statements must be available for review by the editors if necessary.

Plagiarism Policy: Whether intentional or not, plagiarism is a serious violation. The Journal defines plagiarism as a case in which a paper reproduces another work with at least 25% similarity and without attribution. If evidence of plagiarism is found before/after acceptance or after publication of the paper, the author will be offered a chance for rebuttal. If the arguments are not found to be satisfactory, the manuscript will be retracted and the author sanctioned from publishing papers for a period to be determined by the responsible Editor(s).




Conflict of Interest

Any financial (funding, stocks, patents, employment, honoraria, royalties) or nonfinancial (political, personal, professional) interests/relationships that may be interpreted to have influenced the manuscript must be identified in a Conflicts of Interest statement at the end of the manuscript. If there is no conflict of interest, please state: “The authors declare no conflicts of interest.”




Self-Archiving

Karger Publishers permits authors of Open Access articles to post the final, published version of their article in Open Access repositories or on other websites, in accordance with the relevant Creative Commons license. Re-posted Open Access articles must:
  • Follow the terms of the relevant Creative Commons license
  • Be linked to the final version on www.karger.com
  • Include the following statement:
    “The final, published version of this article is available at http://www.karger.com/?doi=[insert DOI number] (e.g. http://www.karger.com/?doi=10.1159/000365070).”
It is the author’s responsibility to fulfil these requirements.

Articles to be archived in PubMed Central for any reason, including funding requirements, must be submitted by Karger (see below).




NIH-Funded Research

The US National Institutes of Health (NIH) Public Access Policy mandates that final, peer-reviewed manuscripts are archived in its digital database PubMed Central (PMC) within 12 months of the official publication date. As a service to authors, Karger Publishers submits the final, published version of Open Access NIH-funded articles to PMC immediately upon publication. The paper usually receives a PMCID within approximately a month. Karger also complies with other funders’ requirements (including Wellcome Trust and RCUK) for submission to PMC. Authors should include information on their grants in the Acknowledgements section of their papers.




Authors' Contributions

Criteria of Authorship: To meet the criteria of authorship, it is necessary to have taken a significant part in the overall conception and design of the research or to have participated in the acquisition, analysis, and interpretation of data as well as to have written initial drafts of the manuscript, and revised and contributed to the final manuscript. Simply having been a part of the research group or having contributed to data collection or having provided patients or analysis of tests is not sufficient to satisfy the criteria of authorship.

Once a paper has been accepted, the Journal does not consider requests to add, delete, or rearrange the sequence of the authors. Before a manuscript is accepted for publication, the corresponding author must send requests to add, remove, or rearrange the authors’ names to the Editor-in-Chief. Requests must include justification for adding or removing authors’ names or altering the sequence of names. Written confirmation signed by all authors, attesting that they agree to the addition, removal, or rearrangement of names is required. In the case of the addition or removal of authors, the author being added or removed must confirm assent. Requests that are not sent by the corresponding author will not be considered after authorship has been agreed.




Charges

Page Charges
Publication in Medical Principles and Practice is not subject to page charges.

Color Figures
Online Edition: Color illustrations are reproduced free of charge in the online edition. In the print version, the illustrations are reproduced in black and white. Please avoid referring to the colors in the text and figure legends.
Print Edition: Up to 6 color illustrations per page can be integrated within the text at CHF 960.– per page.




Use of the Digital Object Identifier (DOI)

S. Karger Publishers supports DOIs as unique identifiers for articles. A DOI number will be printed on the title page of each article. DOIs can be useful in the future for identifying and citing articles published online without volume or issue information. More information can be found at www.doi.org.



Preparing Your Manuscript


Article Types

Original Papers
Original Research Studies include laboratory and clinical investigations as well as research not previously published or being considered for publication elsewhere. A Research Paper may describe new developments or strategies or innovative methods or novel results. Original Research Papers are judged on the quality of their scientific content and contribution to existing knowledge.
Original papers are limited to approximately 19 pages double spaced using 12-point Times New Roman font, including a maximum of 30 references, and all tables and figures. The text should contain a Title page, a Significance of the Study statement, an Abstract, an Introduction, Materials and Methods (laboratory investigations) or Subjects and Methods (clinical investigations), Results, a Discussion, a Conclusion, Acknowledgements (if any), References, Tables, Figure Legends, and Figures in this order. Allow 1 page per figure or table.

Short Communications
A Short Communication is an independent, concise report representing a significant contribution to the health sciences field. Short Communications are used to report important preliminary original research findings that are novel or groundbreaking and need only demonstrate a “proof of principle.” Authors are encouraged to submit an Original Research Paper following their Short Communication.
Short Communications follow the structure of Original Papers but are limited to 6 manuscript pages (approximately 1,000 words) including a maximum of 10 references and 1 table or figure.

Case Reports
These report the signs, symptoms, diagnosis, treatment, and follow-up of individual patients. To be considered for publication, a Case Report must describe an unusual or new occurrence. For example, the case may describe rare features of a disease or a new therapeutic approach, or an unexpected association between symptoms and disease, or an unexpected event in the treatment of the patient, or findings that lead to new insight on the possible pathogenesis of a disease.
Case Reports should contain a Title page, a Significance of the Study statement, an Abstract, an Introduction, Case Report(s), a Discussion that outlines the importance of the case(s) reported, and a Conclusion, and are limited to 6 pages double spaced using 12-point Times New Roman font, including a maximum of 10 references and any tables and figures. Figures and tables follow the text of the manuscript. Allow 1 page per figure or table.

Review Articles
Reviews are articles on research of current interest and are also subject to peer review. Reviews present and critically evaluate the current state of a field with illustrative examples from authoritative sources to convey an indication of trends and likely future developments and provide a list of important references in the current literature. A simple “review of the literature” is not acceptable.
Review Articles are solicited by the Journal on research of current interest and are limited to 35 pages including references, tables, and figures. There is no specified limit for the number of references.

Mini Reviews
Mini Reviews are abbreviated reviews on research of current interest and are limited to 5 pages including references, tables, and figures. The limit for references is 10 and 1–2 tables and/or figures.

Letters to the Editor
Letters may comment on previously published articles or issues of interest to the public. They should be concise and to the point. Letters commenting on previously published articles should be received within 1 year of publication of the said article. They should be limited to 2 pages including a maximum of 5 references and no tables or figures.

Protocols
The Journal publishes protocols of ongoing research projects. If the study has been completed, it will not be considered. Protocols must comply with the following requirements:
The registration number of the protocol from the appropriate authority must be cited. The review of the protocol must be submitted by the authors.
Evidence of ethical approval for such a study from the ethics committee of the institution must be provided by the authors.
The protocol must be structured to include the following relevant areas: Title, Abstract, Introduction, Methods, Expected End Points and Outcomes, References according to the format of Medical Principles and Practice, Funding/Conflict of Interest statement, and Authors’ Contribution to the design of the protocol.




Title Page

The title page must include the title of the article and the list and sequence of all authors and their institutional affiliation(s), the name of the corresponding author and the complete institutional (postal) address, telephone number, email address, a short title and key words. See example of title page




Significance of the Study

A clear Significance of the Study statement must be provided as described below for:

Original Papers (60 words) / Short Communications (40 words)
State the problem and the goal or rationale of the study.
State the new findings. What is novel about this study?
  • For basic studies, how might the finding(s) influence future studies or contribute to the advancement of scientific knowledge?
  • For clinical studies, how will the finding(s) impact clinical practice?

Case Reports (40 words)
State what is unique about this case (other than being rare).
  • What was the outcome and follow-up?
  • How will this case impact clinical practice?

Review Articles (100 words)
State the importance of the field.
  • What are the current trends, critical concerns, and likely future developments?
  • How does your review add to the understanding of this field?




Abstract
The structure of the abstract depends on the type of paper.

Original Papers
250 word limit. Include four clearly identifiable areas of content:
Objective: the purpose of the research
Materials/Subjects and Methods: description of the materials, animals or subjects, basic design, procedures and the analytical techniques including a brief description of statistical analysis
Results: major findings and their importance
Conclusion: significant finding(s) and implication of the finding(s)

Short Communications
150 word limit. Include four clearly identifiable areas of content:
Objective: the purpose of the research
Materials/Subjects and Methods: description of the materials, animals or subjects, basic design, procedures and the analytical techniques including a brief description of statistical analysis
Results: major findings and their importance
Conclusion: significant finding(s) and implication of the finding(s)

Case Reports
100 word limit. Include three clearly identifiable areas of content:
Objective: the purpose of reporting this case
Clinical Presentation and Intervention: a brief description of the case including diagnosis, treatment, final outcome and clinical importance
Conclusion: significant finding(s) and implication of the finding(s)

Review Articles
250 word limit. Not structured (do not include identifiable areas of Objective, Subjects/Materials and Methods, Results, and Conclusion). Summary of the review, including what is known, what is new, and the significance of the review.

Mini Reviews
100 word limit. Not structured (do not include identifiable areas of Objective, Subjects/Materials and Methods, Results, and Conclusion). Summary of the mini review, including what is known, what is new, and the significance of the review.



Arrangement

Text: Manuscripts should be double spaced using 12-point Times New Roman font. The pages of the manuscript should be numbered sequentially starting with the title page as number 1. Major section headings should be bold; subheadings should be italicized only. In-text citations should be numbered consecutively in the text using Arabic numerals placed in [square brackets]. Page breaks should separate the title page, significance of the study, abstract, and the body of the manuscript, which begins with the Introduction and ends with the Conclusion. Acknowledgements (if any) should be on a separate page following the Conclusion of the body of the manuscript. The reference list should be put below on a separate page (see format for references below). Any tables (including their headings) should be placed after this on a separate page. The page with the figure legends should appear after the tables on a separate page. Each figure should be on a separate page.

Abbreviations should be explained the first time they appear in the abstract and in the text. The use of acronyms is discouraged. Generic names should be used.

Scientific measurements should be given in SI units. Any statistical procedure used should be either described in detail or supported by references. The actual calculated p values should be given.

Tables
  • Do not incorporate tables in the main text.
  • Tables must be numbered using Arabic numerals (e.g. Table 1, Table 2).
  • A table should consist of a title, a table head, and a body and, if necessary, footnotes. Use a line to separate these parts.
  • Do not use spaces in tables, use the tabulator.
  • Edit operation data (e.g. 15.1 × 7.23) into one line in the same column.
  • Do not use boldface, italics or shading in the tables.
  • Each table must be cited in the text numerically.
  • Tables should be in Word format.
Illustrations: Figures must be numbered using Arabic numerals (e.g. Fig. 1, Fig. 2) and included in the document file, and they should also be submitted as separate files according to the instructions below. Figures require a legend, which must provide sufficient information to stand alone. Each figure must be cited in the text numerically. Whenever possible, group several illustrations in a block for reproduction (maximum size 180 × 223 mm). b/w halftone and color figures must have a final resolution of 300 dpi after scaling to final size, line drawings one of 1,200 dpi. Color figures must be in RGB format. All figures should be in a common format such as JPG, PSD, TIF, PNG, EPS, or WMF. Vector graphics should be in PPT, AI, or EPS format. Do not send as a PDF.

Multimedia Files: Multimedia files should be submitted in a separate file with the original manuscript and with all subsequent submissions. Multimedia material must meet production quality standards for publication without the need for any modification or editing. Acceptable files are MPEG, AVI, or QuickTime formats.




Supplementary Material

Supplementary files enhance a publication. Supplementary files (directly relevant but not essential to the conclusions of the paper) will undergo editorial review and should be submitted in a separate file with the original manuscript and with all subsequent submissions. The Editors reserve the right to limit the scope and length of the supplementary material. Supplementary material must meet production quality standards for publication without the need for any modification or editing. Files should not exceed 10 MB in size. Figures and tables must have titles and legends and all files must be supplied separately and named clearly. Acceptable files and formats are Word or PDF files, Excel spreadsheets (if the data cannot easily be converted to a PDF file), and multimedia files (MPEG, AVI, or QuickTime formats). All supplementary material should be referred to in the main text.




References

In-Text Citations: References should be numbered consecutively in the text using Arabic numerals enclosed in [square brackets].

References should be listed in the order in which they are cited in the text. Manuscripts accepted for print and online publication may be cited with the DOI. Write the last names of the authors followed by the initials with no punctuation other than a comma to separate the names. When there are more than three authors write only the first three names followed by et al. The final name or et al should be followed by a colon and the title of the article with only the first word capitalized (lower case for the remainder of the title). List the standard abbreviated name of the journal, the year of publication, the volume, and the complete range of pages. Use abbreviated journal names according to the Index Medicus system. See also International Committee of Medical Journal Editors: Uniform requirements for manuscripts submitted to biomedical journals (www.icmje.org).

Examples
(a) Papers published in periodicals:
  1. Long C, Li M: Age and stroke severity: hazards for intravenous thrombolysis? Med Princ Pract 2016;25:99–100.
  2. Aksoy O, Parlak E, Parlak M, et al: Serum β-defensin-2 levels and their relationship with the clinical course and prognosis in patients with Crimean-Congo hemorrhagic fever. Med Princ Pract 2016;25:163–168.
(b) Papers published only with DOI numbers:
  1. Khallaf FG, Kehinde EO, Hussein S: Bone healing and hormonal bioassay in patients with long bone fractures and concomitant head injury. Med Princ Pract DOI: 10.1159/000445250.
(c) Monographs:
  1. Matthews DE, Farewell VT: Using and Understanding Medical Statistics, ed 5, revised. Basel, Karger, 2015.
(d) Edited books:
  1. DuBois RN: Cyclooxygenase-2 and colorectal cancer; in Dannenberg AJ, Dubois RN (eds): COX-2. Prog Exp Tum Res. Basel, Karger, 2003, vol 37, pp 124–137.
(e) Websites with access date:
  1. World Health Organization: Leprosy elimination project: status report. 2003. http://www.who.int/lep/Reports/s20042.pdf (accessed May 15, 2005).
Reference Management Software
The use of EndNote© is recommended for easy management and formatting of citations and reference lists. Click on the link to access the style of Medical Principles and Practice:
EndNote©: http://endnote.com/downloads/style/medical-principles-and-practice




Language


Usage and Editing Services

The official language of Medical Principles and Practice is American English. Authors who require editing to eliminate grammatical, usage, and spelling errors and who would like confirmation that their text meets the standards of correct scientific English may wish to consult an English Language Editing service. For recommendations, please see http://www.karger.com/Resources/Authors.




Submission


Submitting Your Manuscript

Follow the instructions and prompts on the screen to upload your manuscript file that includes tables and figures if any and then the figure files separately, if any. The server will generate a PDF file to be used for review.

Submit the manuscript as one file that includes all elements of the text: Title page, Abstract, Significance of the Study statement, Text, References, Tables, page containing Figure Legends, and Figures.

For image precision, upload the figures as tiff or jpg files separately in addition to including them as a part of the manuscript text file.

The final screen is the confirmation screen with your temporary transaction number.

You may cancel your submission at any stage during the process by clicking the “Cancel Submission” button.

Please do not use the “Back” button on your browser. You will be able to go back from the final screen and add any files you may have overlooked.

After submission, the data and files will be reviewed by the Editorial Office and you will then receive an acknowledgement by email with a manuscript number. Your personal information (including login name and password) will not be updated until then.

Before proceeding, we encourage you to read the Guidelines for Authors for specific directions on how to prepare your manuscript.

Should you experience any problems with your submission, please contact:

Professor Azu Owunwanne
Editor-in-Chief
Medical Principles and Practice
Health Sciences Centre
Kuwait University
PO Box 24923
Safat 13110 (Kuwait)
Tel. +965 2534 0479
Fax +965 2533 3094
E-Mail mpp@hsc.edu.kw




Submission Statement

A Submission Statement signed by all authors must be received by the editorial office. Please print and sign the form, and upload it during submission (or fax or scan and email it) to make it legally binding.




Cover Letter

All manuscripts should be accompanied by a cover letter from the corresponding author. Please note the Journal only corresponds with the corresponding author. The cover letter must state that the manuscript is not under simultaneous consideration by any other journal, has not been previously published, all co-authors have made a significant contribution to the manuscript, the study complies with ethical standards, and all authors disclose any conflict of interest.




Submission Checklist

Cover Letter: The cover letter must state that the manuscript is not under simultaneous consideration by any other journal, has not been previously published, all co-authors have made a significant contribution to the manuscript, the study complies with ethical standards, and none of the authors have any conflict of interest.

Title Page: The title page must include the title of the manuscript, a list and sequence of co-authors, and the corresponding author’s address including telephone number and email address. Provide a short title and key words.

Abstract: Check that the abstract conforms to the requirements for the type of paper.

Significance of the Study: Check that you have provided brief answers to the questions about the type of paper. Remember, the Significance of the Study is intended to guide the author to articulate what is original and/or how the study contributes to knowledge in the field.

Text of the Manuscript: Check the page limit/figure and table limits for the type of paper. The manuscripts should be double spaced using Times New Roman font. Use bold for headings and italics for subheadings. Use square brackets for in-text citations.

References: These must conform to the format of Medical Principles and Practice.

Tables: Provide a separate page for each table. The title precedes the table. Footnotes follow the table. Any abbreviations must be explained in the footnotes.

Figures/Illustrations:
  • Use .jpg, .tiff, or .ppt file format.
  • Prepare each figure on a separate page.
  • Provide a Figure Legend page.
  • Upload figures separately as well as including them as a part of the text of the manuscript.
  • Do not use a screen background for figures.
  • Electronically submitted b/w halftone and color illustrations must have a final resolution of 300 dpi after scaling, line drawings one of 800–1,200 dpi.
  • Photomicrographs should be calibrated on the print by adding a calibration bar (e.g. bar = 1 µm).
  • Obtain written consent from the copyright holders for any re-publication of figures.
  • Conceal the identity of patients or provide written consent.

Online Manuscript Submission





After Acceptance


Advanced Release

Papers are published online in unedited, original manuscript format within 24 hours and also appear on PubMed within 48 hours.




Copy Editing and Proofing

Manuscripts accepted for publication by Karger Publishers are subject to copyediting. Authors should check the changes introduced by the copy editor and answer any questions that might have arisen during proofreading.

An email containing a link to download the proofs will be sent to the corresponding author. Proofs should be returned within 48 hours. Alterations made in proofs, other than the correction of printer's (introduced) errors, are charged to the author and may require editorial approval.




Reprints

A quotation for reprints can be requested at the time of the approval-to-print. Orders submitted after the issue has been printed are subject to considerably higher prices.




Author Inquires


From Submission to Acceptance

For inquiries relating to the submission of articles (including electronic submission), please email the Editorial Office of Medical Principles and Practice at mpp@hsc.edu.kw.




After Acceptance

Contact details for questions arising after acceptance of an article, especially those relating to proofs, will be provided by the publisher.