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Neurodegenerative Diseases

Translational Research on the Nervous System

Vol. 7, No. 1-3, 2010

Issue release date: April 2010

Alzheimer's and Parkinson's Diseases: Advances, Concepts and New Challenges

9th International Conference AD/PD, Prague, March 2009: Proceedings

See also ISBN 978-3-8055-9358-8 for more details
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Special Section

Title Page / Table of Contents

Neurodegenerative Dis 2010;7:1–4 (DOI:10.1159/000313305)
Free Access


Windisch M. · Nitsch R. · Fisher A. · Hanin I.
Neurodegenerative Dis 2010;7:5 (DOI:10.1159/000283473)
Free Access
History of Dementia Research

History of Dementia Research in Bohemia and Middle Europe

Kalvach P. · Kalvach Z.
Neurodegenerative Dis 2010;7:6–9 (DOI:10.1159/000283474)
Biology of Neurodegeneration

Dissecting Toxicity of Tau and β-Amyloid

Götz J. · Lim Y.-A. · Ke Y.D. · Eckert A. · Ittner L.M.
Neurodegenerative Dis 2010;7:10–12 (DOI:10.1159/000283475)

Tau Kinase I Overexpression Induces Dentate Gyrus Degeneration

Avila J. · Gómez de Barreda E. · Engel T. · Pérez M. · Martín-Maestro P. · Fuster-Matanzo A. · Goñi-Oliver P. · Lucas J.J. · Hernández F.
Neurodegenerative Dis 2010;7:13–15 (DOI:10.1159/000283476)

Possible Role of Tau in Mediating Pathological Effects of apoE4 in vivo prior to and following Activation of the Amyloid Cascade

Inbar D. · Belinson H. · Rosenman H. · Michaelson D.M.
Neurodegenerative Dis 2010;7:16–23 (DOI:10.1159/000283477)

Transition of Tau Protein from Disordered to Misordered in Alzheimer’s Disease

Kovacech B. · Skrabana R. · Novak M.
Neurodegenerative Dis 2010;7:24–27 (DOI:10.1159/000283478)

‘Prion-Like’ Propagation of Mouse and Human Tau Aggregates in an Inducible Mouse Model of Tauopathy

Sydow A. · Mandelkow E.-M.
Neurodegenerative Dis 2010;7:28–31 (DOI:10.1159/000283479)

Are Aβ and Its Derivatives Causative Agents or Innocent Bystanders in AD?

Robakis N.K.
Neurodegenerative Dis 2010;7:32–37 (DOI:10.1159/000266476)
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Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

Eikelenboom P. · van Exel E. · Hoozemans J.J.M. · Veerhuis R. · Rozemuller A.J.M. · van Gool W.A.
Neurodegenerative Dis 2010;7:38–41 (DOI:10.1159/000283480)

Analysis of APL1β28, a Surrogate Marker for Alzheimer Aβ42, Indicates Altered Precision of γ-Cleavage in the Brains of Alzheimer Disease Patients

Okochi M. · Tagami S. · Takeda M.
Neurodegenerative Dis 2010;7:42–45 (DOI:10.1159/000283481)

Expression of Familial Alzheimer’s Disease-Linked Human Presenilin 1 Variants Impair Enrichment-Induced Adult Hippocampal Neurogenesis

Veeraraghavalu K. · Choi S.H. · Sisodia S.S.
Neurodegenerative Dis 2010;7:46–49 (DOI:10.1159/000283482)

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

Checler F. · Dunys J. · Pardossi-Piquard R. · Alves da Costa C.
Neurodegenerative Dis 2010;7:50–55 (DOI:10.1159/000283483)

Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons

Wang X. · Perry G. · Smith M.A. · Zhu X.
Neurodegenerative Dis 2010;7:56–59 (DOI:10.1159/000283484)
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Acetylcholinesterase Variants in Alzheimer’s Disease: From Neuroprotection to Programmed Cell Death

Greenberg D.S. · Toiber D. · Berson A. · Soreq H.
Neurodegenerative Dis 2010;7:60–63 (DOI:10.1159/000285507)

Neuroprotective and Neurotoxic Phenotypes of Activated Microglia in Neonatal Mice with Respective MPTP- and Ethanol-Induced Brain Injury

Sawada H. · Suzuki H. · Nagatsu T. · Sawada M.
Neurodegenerative Dis 2010;7:64–67 (DOI:10.1159/000285508)

LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins

Hsu C.H. · Chan D. · Wolozin B.
Neurodegenerative Dis 2010;7:68–75 (DOI:10.1159/000285509)
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Misframed Proteins and Neurodegeneration: A Novel View on Alzheimer’s and Parkinson’s Diseases

Dennissen F.J.A. · Kholod N. · Steinbusch H.W.M. · Van Leeuwen F.W.
Neurodegenerative Dis 2010;7:76–79 (DOI:10.1159/000285510)

Impaired Neurotransmitter Release in Alzheimer’s and Parkinson’s Diseases

Shen J.
Neurodegenerative Dis 2010;7:80–83 (DOI:10.1159/000285511)
Free Access

Stem Cell Biology in the Study of Pathological Conditions

Sugaya K.
Neurodegenerative Dis 2010;7:84–87 (DOI:10.1159/000285512)
Disease Models

Possible Involvement of Transthyretin in Hippocampal β-Amyloid Burden and Learning Behaviors in a Mouse Model of Alzheimer’s Disease (TgCRND8)

Doggui S. · Brouillette J. · Chabot J.-G. · Farso M. · Quirion R.
Neurodegenerative Dis 2010;7:88–95 (DOI:10.1159/000285513)

Early-Stage Inflammation and Experimental Therapy in Transgenic Models of the Alzheimer-Like Amyloid Pathology

Cuello A.C. · Ferretti M.T. · Leon W.C. · Iulita M.F. · Melis T. · Ducatenzeiler A. · Bruno M.A. · Canneva F.
Neurodegenerative Dis 2010;7:96–98 (DOI:10.1159/000285514)

Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo

Paquet D. · Schmid B. · Haass C.
Neurodegenerative Dis 2010;7:99–102 (DOI:10.1159/000285515)

Generation of Tau Aggregates and Clearance by Autophagy in an Inducible Cell Model of Tauopathy

Wang Y. · Krüger U. · Mandelkow E. · Mandelkow E.-M.
Neurodegenerative Dis 2010;7:103–107 (DOI:10.1159/000285516)

Silencing/Overexpressing Selected Genes as a Model of Sporadic Parkinson’s Disease

Fishman-Jacob T. · Youdim M.B.H. · Mandel S.A.
Neurodegenerative Dis 2010;7:108–111 (DOI:10.1159/000285517)
Relationship Between Cerebrovascular Lesions and Primary Neurodegenerative Diseases

Prevalence and Impact of Cerebrovascular Lesions in Alzheimer and Lewy Body Diseases

Jellinger K.A.
Neurodegenerative Dis 2010;7:112–115 (DOI:10.1159/000285518)

The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond

de la Torre J.C.
Neurodegenerative Dis 2010;7:116–121 (DOI:10.1159/000285520)

Vascular Dementia and Alzheimer’s Disease – Are We in a Dead-End Road?

Cavalieri M. · Enzinger C. · Petrovic K. · Pluta-Fuerst A. · Homayoon N. · Schmidt H. · Fazekas F. · Schmidt R.
Neurodegenerative Dis 2010;7:122–126 (DOI:10.1159/000285521)

Vascular Contribution to Dementia in Parkinson’s Disease

Korczyn A.D.
Neurodegenerative Dis 2010;7:127–130 (DOI:10.1159/000285522)
Imaging, Biomarkers, Genetics and Diagnostic Markers

Early Detection of Alzheimer’s Disease with PET Imaging

Berti V. · Osorio R.S. · Mosconi L. · Li Y. · De Santi S. · de Leon M.J.
Neurodegenerative Dis 2010;7:131–135 (DOI:10.1159/000289222)
Free Access

Amyloid Imaging in Early Detection of Alzheimer’s Disease

Nordberg A.
Neurodegenerative Dis 2010;7:136–138 (DOI:10.1159/000289223)

Inability of Plasma and Urine F2A-Isoprostane Levels to Differentiate Mild Cognitive Impairment from Alzheimer’s Disease

Mufson E.J. · Leurgans S.
Neurodegenerative Dis 2010;7:139–142 (DOI:10.1159/000289224)
Free Access

Increased CD44 Gene Expression in Lymphocytes Derived from Alzheimer Disease Patients

Uberti D. · Cenini G. · Bonini S.A. · Barcikowska M. · Styczynska M. · Szybinska A. · Memo M.
Neurodegenerative Dis 2010;7:143–147 (DOI:10.1159/000289225)

Human Analogue of the Morris Water Maze for Testing Subjects at Risk of Alzheimer’s Disease

Laczó J. · Andel R. · Vyhnalek M. · Vlcek K. · Magerova H. · Varjassyova A. · Tolar M. · Hort J.
Neurodegenerative Dis 2010;7:148–152 (DOI:10.1159/000289226)

Social Odor Recognition: A Novel Behavioral Model for Cognitive Dysfunction in Parkinson’s Disease

Monaghan M.M. · Leddy L. · Sung M.-L.A. · Albinson K. · Kubek K. · Pangalos M.N. · Reinhart P.H. · Zaleska M.M. · Comery T.A.
Neurodegenerative Dis 2010;7:153–159 (DOI:10.1159/000289227)

Cognitive Event-Related Potentials and Oscillations in the Subthalamic Nucleus

Rektor I. · Baláž M. · Bočková M.
Neurodegenerative Dis 2010;7:160–162 (DOI:10.1159/000289228)

Oophorectomy, Menopause, Estrogen, and Cognitive Aging: The Timing Hypothesis

Rocca W.A. · Grossardt B.R. · Shuster L.T.
Neurodegenerative Dis 2010;7:163–166 (DOI:10.1159/000289229)
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Pharmacogenomic Protocols in CNS Disorders and Dementia

Cacabelos R.
Neurodegenerative Dis 2010;7:167–169 (DOI:10.1159/000289230)

Common Variant in GRN Is a Genetic Risk Factor for Hippocampal Sclerosis in the Elderly

Dickson D.W. · Baker M. · Rademakers R.
Neurodegenerative Dis 2010;7:170–174 (DOI:10.1159/000289231)
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Leucine-Rich Repeat Kinase 2 Gene-Associated Disease: Redefining Genotype-Phenotype Correlation

Wider C. · Dickson D.W. · Wszolek Z.K.
Neurodegenerative Dis 2010;7:175–179 (DOI:10.1159/000289232)
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Treatment and Prevention

Lipid-Lowering Treatment Is Related to Decreased Risk of Dementia: A Population-Based Study (FINRISK)

Solomon A. · Sippola R. · Soininen H. · Wolozin B. · Tuomilehto J. · Laatikainen T. · Kivipelto M.
Neurodegenerative Dis 2010;7:180–182 (DOI:10.1159/000295659)

Cholesterol and Cognitive Performance in Normal Controls and the Influence of Elective Statin Use after Conversion to Mild Cognitive Impairment: Results in a Clinical Trial Cohort

Sparks D.L. · Kryscio R.J. · Connor D.J. · Sabbagh M.N. · Sparks L.M. · Lin Y. · Liebsack C.
Neurodegenerative Dis 2010;7:183–186 (DOI:10.1159/000295660)
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Effect of Heparin on APP Metabolism and Aβ Production in Cortical Neurons

Klaver D. · Hung A.C. · Gasperini R. · Foa L. · Aguilar M.-I. · Small D.H.
Neurodegenerative Dis 2010;7:187–189 (DOI:10.1159/000295661)

Retinoids as a Perspective in Treatment of Alzheimer’s Disease

Fahrenholz F. · Tippmann F. · Endres K.
Neurodegenerative Dis 2010;7:190–192 (DOI:10.1159/000295662)

Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants

Cornelli U.
Neurodegenerative Dis 2010;7:193–202 (DOI:10.1159/000295663)

Filamentous Phages Reduce α-Synuclein Oligomerization in the Membrane Fraction of SH-SY5Y Cells

Dimant H. · Solomon B.
Neurodegenerative Dis 2010;7:203–205 (DOI:10.1159/000295664)

Effects of Dopamine Agonists on Neuropsychiatric Symptoms of Parkinson’s Disease

Rektorová I.
Neurodegenerative Dis 2010;7:206–209 (DOI:10.1159/000295665)

Future Strategies for Neuroprotection in Parkinson’s Disease

Schapira A.H.V.
Neurodegenerative Dis 2010;7:210–212 (DOI:10.1159/000295666)

The Concept of Continuous Dopaminergic Stimulation: What We Should Consider when Starting Parkinson’s Disease Treatment

Stocchi F.
Neurodegenerative Dis 2010;7:213–215 (DOI:10.1159/000295667)
Further Section

Author Index Vol. 7, No. 1–3, 2010

Neurodegenerative Dis 2010;7:216 (DOI:10.1159/000313306)
Free Access

Subject Index Vol. 7, No. 1–3 2010

Neurodegenerative Dis 2010;7:217–218 (DOI:10.1159/000313307)
Free Access