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Vol. 233, No. 2-3, 2017

Issue release date: October 2017

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Are There Indications for Isotretinoin Treatment of Hidradenitis Suppurativa?

Boer J.
Dermatology 2017;233:111-112 (DOI:10.1159/000477615)
link Key Message: Patients with both acne and HS being treated with isotretinoin can normally expect a cure of their acne but not of their HS.
Free Access
Review Paper

Swiss Practice Recommendations for the Management of Hidradenitis Suppurativa/Acne Inversa

Hunger R.E. · Laffitte E. · Läuchli S. · Mainetti C. · Mühlstädt M. · Schiller P. · Lapointe A.-K. · Meschberger P. · Navarini A.A.
Dermatology 2017;233:113-119 (DOI:10.1159/000477459)
link -Key Message: Hidradenitis suppurativa is one of the most neglected chronic inflammatory skin diseases.
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Original Paper

A New Perspective on Isotretinoin Treatment of Hidradenitis Suppurativa: A Retrospective Chart Review of Patient Outcomes

Huang C.M. · Kirchhof M.G.
Dermatology 2017;233:120-125 (DOI:10.1159/000477207)
link -Key Message: Isotretinoin can treat hidradenitis suppurativa, particularly in acne-prone younger females with mild disease.
-Free Supplementary Material
Free Access
Basic Science Investigations

Serum Anticytokine Autoantibody Levels Are Not Increased in Hidradenitis Suppurativa: A Case-Control Pilot Study

Theut Riis P. · von Stemann J.H. · Kjærsgaard Andersen R. · Hansen M.B. · Jemec G.B.E.
Dermatology 2017;233:126-128 (DOI:10.1159/000475925)
link -Key Message: Endogenously produced autoantibodies only play a minor role, if any, in hidradenitis suppurativa.
-Free Supplementary Material
Free Access
Original Paper

Altered Global 5-Hydroxymethylation Status in Hidradenitis Suppurativa: Support for an Epigenetic Background

Hessam S. · Sand M. · Lang K. · Käfferlein H.U. · Scholl L. · Gambichler T. · Skrygan M. · Brüning T. · Stockfleth E. · Bechara F.G.
Dermatology 2017;233:129-135 (DOI:10.1159/000478043)
link -Key Message: Our results indicate a disturbed DNA hydroxymethylation status in the inflammatory microenvironment in hidradenitis suppurativa.
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Clinical Investigations

Acne Fulminans: Treatment Experience from 26 Patients

Massa A.F. · Burmeister L. · Bass D. · Zouboulis C.C.
Dermatology 2017;233:136-140 (DOI:10.1159/000473860)
link -Key Message: The isotretinoin/prednisolone scheme showed a good efficacy in controlling systemic signs and improving skin lesions.
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Free Access
Review Paper

Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study

Grandhi R. · Alikhan A.
Dermatology 2017;233:141-144 (DOI:10.1159/000471799)
link -Key Message: Spironolactone is a safe medication for postadolescent female acne.
-Free Supplementary Material
Free Access
Original Paper

Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City

Pereira Duquia R. · da Silva dos Santos I. · de Almeida Jr. H. · Martins Souza P.R. · de Avelar Breunig J. · Zouboulis C.C.
Dermatology 2017;233:145-154 (DOI:10.1159/000475775)
link -Key Message: Male adolescents in Brazil present a high prevalence of acne (89.1%), mostly with both inflammatory and noninflammatory lesions. Inflammatory lesions are more prominent in light phototype patients, while noninflammatory ones in dark phototype adolescents. Height is directly associated with the occurrence of acne.
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The Effects of Human Beta-Defensins on Skin Cells in vitro

van Kilsdonk J.W.J. · Jansen P.A.M. · van den Bogaard E.H. · Bos C. · Bergers M. · Zeeuwen P.L.J.M. · Schalkwijk J.
Dermatology 2017;233:155-163 (DOI:10.1159/000477346)
link -Key Message: hBDs exert modest biological effects on skin cells that are potentially beneficial in wound healing.
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Serum Human Beta-Defensin-2 Is a Possible Biomarker for Monitoring Response to JAK Inhibitor in Psoriasis Patients

Jin T. · Sun Z. · Chen X. · Wang Y. · Li R. · Ji S. · Zhao Y.
Dermatology 2017;233:164-169 (DOI:10.1159/000475809)
link -Key Message: Serum hBD-2 is a possible biomarker for monitoring response to JAK inhibitor in psoriasis patients.
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Free Access

Untreated Psoriasis Impairs Male Fertility: A Case-Control Study

Caldarola G. · Milardi D. · Grande G. · Quercia A. · Baroni S. · Morelli R. · Marana R. · Pontecorvi A. · De Simone C. · Peris K.
Dermatology 2017;233:170-174 (DOI:10.1159/000471849)
link -Key Message: Untreated psoriasis may impair male fertility at a hormonal and seminal level.
-Free Supplementary Material
Free Access

The Implications of Recent Recommendations for Managing Patients with Psoriasis Treated with Fumaric Acid Esters

Foley C.C. · Molloy O.E. · Lally A. · Kirby B.
Dermatology 2017;233:175-177 (DOI:10.1159/000479792)
link -Key Message: There is a lack of evidence base to support recent recommendations on the use of fumaric acid esters.
- Free Supplementary Material
Free Access

Early Visible Improvements during K101-03 Treatment: An Open-Label Multicenter Clinical Investigation in Patients with Onychomycosis and/or Nail Psoriasis

Piraccini B.M. · Starace M. · Toft A.
Dermatology 2017;233:178-183 (DOI:10.1159/000478257)
link -Key Message: Patients with onychomycosis and/or nail psoriasis report improvements after just 1 week of K101-03 treatment.
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Open Access Gateway
Skin Cancer - Original Paper

Dermoscopic Features of Subungual Squamous Cell Carcinoma: A Study of 44 Cases

Teysseire S. · Dalle S. · Duru G. · Phan A. · Debarbieux S. · Poulhalon N. · Thomas L.
Dermatology 2017;233:184-191 (DOI:10.1159/000479059)
link -Key Message: We report the first large series of both clinically and dermoscopically studied cases of subungual squamous cell carcinoma.
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Free Access
Original Paper

Ultraviolet A1 Phototherapy in the Treatment of Early Mycosis Fungoides

Adışen E. · Tektaş V. · Erduran F. · Erdem Ö. · Gürer M.A.
Dermatology 2017;233:192-198 (DOI:10.1159/000458149)
link -Key Message: UVA1 phototherapy when given at 30 J/cm2 5 times a week for 5 weeks provides clinical and histological healing of early mycosis fungoides.
-Free Supplementary Material
Free Access
Skin Cancer - Original Paper

Non-Melanoma Skin Cancers of the Fronto-Temporal Area Preferentially Localize in the Proximity of Arterial Blood Vessels

Kuonen F. · Gilliet M. · Perrier P.
Dermatology 2017;233:199-204 (DOI:10.1159/000468537)
link -Key Message: Sonographic and histological analyses bring out an anatomical correlation between NMSCs of the fronto-temporal area and arterial blood vessels.
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Free Access

Multiple Lymph Node Basin Drainage in Trunk Melanoma Is Not Associated with Survival of Sentinel Lymph Node-Positive Patients

Ribero S. · Osella Abate S. · Pasquali S. · Rossi C.R. · Borgognoni L. · Piazzalunga D. · Solari N. · Schiavon M. · Brandani P. · Ansaloni L. · Ponte E. · Silan F. · Sommariva A. · Bellucci F. · Macripò G. · Quaglino P. · on behalf of the Italian Melanoma Intergroup (IMI)
Dermatology 2017;233:205-211 (DOI:10.1159/000477457)
link -Key Message: Multiple lymph node basin drainage is not associated with survival in positive sentinel lymph node biopsy patients.
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Similar but Different: How Reflectance Confocal Microscopy May Help in the Diagnosis of Pink Lesions

Ferrari F. · Bassoli S. · Pellacani G. · Argenziano G. · Cesinaro A.M. · Longo C.
Dermatology 2017;233:212-216 (DOI:10.1159/000477539)
link -Key Message: Confocal microscopy improves diagnostic accuracy of challenging solitary pink lesions, avoiding mistreatment of amelanotic melanoma.
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Skin Cancer - Clinical Investigations

Successful Use of Grenz Rays for Disseminated Superficial Actinic Porokeratosis: Report of 8 Cases

Ramelyte E. · Bylaite-Bucinskiene M. · Dummer R. · Imhof L.
Dermatology 2017;233:217-222 (DOI:10.1159/000478855)
link -Key Message: Radiotherapy with grenz rays could be a good treatment option for patients with disseminated superficial actinic porokeratosis.
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Free Access
Review Paper

An Asian Perspective on Povidone Iodine in Wound Healing

Bigliardi P. · Langer S. · Cruz J.J. · Kim S.W. · Nair H. · Srisawasdi G.
Dermatology 2017;233:223-233 (DOI:10.1159/000479150)
link -Key Message: The Asian Working Group presents consensus statements for povidone iodine based on evidence and their experience.
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Original Paper

Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study

Chopinaud M. · Labbé D. · Creveuil C. · Marc M. · Bénateau H. · Mourgeon B. · Chopinaud E. · Veyssière A. · Dompmartin A.
Dermatology 2017;233:234-241 (DOI:10.1159/000478009)
link -Key Message: Adipose tissue is a new therapeutic means for wound repair and tissue regeneration.
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Free Access

Skin-Homing IL-13-Producing T Cells Expand in the Circulation of Patients with Drug Rash with Eosinophilia and Systemic Symptoms

Teraki Y. · Fukuda T.
Dermatology 2017;233:242-249 (DOI:10.1159/000475546)
link -Key Message: IL-13-producing T cells may be involved in the pathogenesis of drug rash with eosinophilia and systemic symptoms.
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Free Access

Long-Term Prognosis of Alopecia Totalis and Alopecia Universalis: A Longitudinal Study with More than 10 Years of Follow-Up: Better than Reported

Jang Y.H. · Hong N.-S. · Moon S.Y. · Eun D.H. · Lee W.K. · Chi S.G. · Kim J.Y. · Lee W.J. · Lee S.-J. · Kim D.W.
Dermatology 2017;233:250-256 (DOI:10.1159/000477458)
link -Key Message: The prognosis of alopecia totalis and alopecia universalis is considered to be better than previously reported.
-Free Supplementary Material
Free Access


Dermatology 2017;233:257 (DOI:10.1159/000479473)
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