Acute Aromatics Inhalation Modifies the Airways. Effects of the Common ColdCohen B.M. · Dressier W.E.
Department of Medicine, The Elizabeth General Hospital (Prof. Dr. Cohen) and Vick Research (Dr. Dressier), Elizabeth, N.J., USA
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
We recorded lung and forced expiratory volumes, nasal, lower and total airway resistances, closing volume data, the phase III slope and MEFV derivatives on air and helium/oxygen breathing for 24 nonsmoking healthy adults with common colds who were then randomly assigned to inhalation of a mixture of aromatic vapors (eucalyptus, menthol, camphor) or a tap water control. Measurements were made after 20 and 60 min of aromatics or control exposure and after intranasal spraying with a 0.25% phenylephrine solution. Gas chromatography of sampling tubes gave the aromatics concentration in the inspired air.Although baseline differences from predicted values were limited to changes in small airways function, except for the reduced peak expiratory flow rate (PEFR) mean, low-density gas breathing responsivity suggested concomitant large airway involvement. Significant changes (p = 0.05) in forced vital capacity, forced expiratory volume for the 3rd s, closing capacity and the phase III slope of the alveolar plateau favored aromatics therapy over the control solution, with marginal volume of isoflow differences showing a similar trend. Intranasal phenylephrine induced statistically significant changes in nasal resistance and in tests of the large and small airways.In confirming the presence of peripheral airways dysfunction in nonsmokers with uncomplicated common colds, our data imply that the changes can be modified favorably by short-term aromatics inhalation. The prompt responses to intranasal phenylephrine suggest that the operation of a nasal-pulmonary reflex arc may be responsible, in part, for the lower airways effects of the aromatics vapor.
© 1982 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.